Neurobiology of Disease Parkinson’s Disease -Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death
نویسندگان
چکیده
Lee J. Martin,1,2 Yan Pan,1 Ann C. Price,1 Wanda Sterling,1 Neal G. Copeland,4 Nancy A. Jenkins,4 Donald L. Price,1,2,3 and Michael K. Lee1 1Department of Pathology, Division of Neuropathology, and Departments of 2Neuroscience and 3Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, and 4Mouse Cancer Genetics Program, National Cancer Institute–Frederick Cancer Center Research and Development Center, Frederick, Maryland 21702
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Human -synuclein-harboring familial Parkinson’s disease-linked Ala-53 3 Thr mutation causes neurodegenerative disease with -synuclein aggregation in transgenic mice
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